“NF-κB signaling in inflammation” (2017), by Ting Liu et al. Genetics and Biochemistry research paper. Original abstract below, unchanged. A free PDF is available.

NF-κB signaling in inflammation

Ting Liu, Lingyun Zhang, Donghyun Joo et al. · July 14, 2017 · Genetics and Biochemistry

Abstract

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.

Free PDF DOI: 10.1038/sigtrans.2017.23