# T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

“T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer” (2016), by Eric Tran et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Eric Tran, Paul F. Robbins, Yong‐Chen Lu, Todd D. Prickett, Jared J. Gartner, Lee Jia, Anna Pasetto, Zhili Zheng, Satyajit Ray, Eric M. Groh et al.
- Published: December 7, 2016
- Field: Immunology and Microbiology
- DOI: https://doi.org/10.1056/nejmoa1609279
- Source: https://doi.org/10.1056/nejmoa1609279

## Abstract

HLA-C*08:02-restricted tumor-infiltrating lymphocytes that were composed of four different T-cell clonotypes that specifically targeted KRAS G12D. However, one of these lesions had progressed on evaluation 9 months after therapy. The lesion was resected and found to have lost the chromosome 6 haplotype encoding the HLA-C*08:02 class I major histocompatibility complex (MHC) molecule. The loss of expression of this molecule provided a direct mechanism of tumor immune evasion. Thus, the infusion of CD8+ cells targeting mutant KRAS mediated effective antitumor immunotherapy against a cancer that expressed mutant KRAS G12D and HLA-C*08:02.

Canonical page: https://nerdi.pages.dev/paper/W2559953355
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