# Palladium-Catalyzed Transformations of Alkyl C–H Bonds

“Palladium-Catalyzed Transformations of Alkyl C–H Bonds” (2016), by Jian He et al. Chemistry research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Jian He, Masayuki Wasa, Kelvin S. L. Chan, Qian Shao, Jin‐Quan Yu
- Published: December 2, 2016
- Field: Chemistry
- DOI: https://doi.org/10.1021/acs.chemrev.6b00622
- Source: https://www.ncbi.nlm.nih.gov/pmc/articles/5516964

## Abstract

This Review summarizes the advancements in Pd-catalyzed C(sp 3 )–H activation via various redox manifolds, including Pd(0)/Pd(II), Pd(II)/Pd(IV), and Pd(II)/Pd(0). While few examples have been reported in the activation of alkane C–H bonds, many C(sp 3 )–H activation/C–C and C–heteroatom bond forming reactions have been developed by the use of directing group strategies to control regioselectivity and build structural patterns for synthetic chemistry. A number of mono- and bidentate ligands have also proven to be effective for accelerating C(sp 3 )–H activation directed by weakly coordinating auxiliaries, which provides great opportunities to control reactivity and selectivity (including enantioselectivity) in Pd-catalyzed C–H functionalization reactions.

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