# Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

“Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions” (2016), by Paula Ruiz‐Castillo et al. Chemistry research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Paula Ruiz‐Castillo, Stephen L. Buchwald
- Published: September 30, 2016
- Field: Chemistry
- DOI: https://doi.org/10.1021/acs.chemrev.6b00512
- Source: https://doi.org/10.1021/acs.chemrev.6b00512

## Abstract

Pd-catalyzed cross-coupling reactions that form C-N bonds have become useful methods to synthesize anilines and aniline derivatives, an important class of compounds throughout chemical research. A key factor in the widespread adoption of these methods has been the continued development of reliable and versatile catalysts that function under operationally simple, user-friendly conditions. This review provides an overview of Pd-catalyzed N-arylation reactions found in both basic and applied chemical research from 2008 to the present. Selected examples of C-N cross-coupling reactions between nine classes of nitrogen-based coupling partners and (pseudo)aryl halides are described for the synthesis of heterocycles, medicinally relevant compounds, natural products, organic materials, and catalysts.

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