# Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

“Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes” (2016), by Laura K. Mackay et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Laura K. Mackay, Martina Minnich, Natasja A. M. Kragten, Yang Liao, Benjamin Nota, Cyril Seillet, Ali Zaid, Kevin Man, Simon Preston, David Freestone et al.
- Published: April 21, 2016
- Field: Immunology and Microbiology
- DOI: https://doi.org/10.1126/science.aad2035
- Source: https://pure.amsterdamumc.nl/files/178269035/Hobit-and-blimp1-instruct-a-universal-transcriptional-program-of-tissue-residency-in-lymphocytes.pdf

## Abstract

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.

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