“Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes” (2016), by Laura K. Mackay et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Laura K. Mackay, Martina Minnich, Natasja A. M. Kragten et al. · April 21, 2016 · Immunology and Microbiology

Abstract

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.

Source page DOI: 10.1126/science.aad2035